范文亮1  李灵丽1   杨炼1   朱朝辉2

（１华中科技大学同济医学院附属协和医院放射科，２华中科技大学同济医学院附属协和医院泌尿外科）

摘要：目的：通过静息态功能磁共振指标分数低频振幅（fALFF），探讨静脉型勃起功能障碍（VED）患者固有自发大脑活动改变，进一步分析这些改变与临床症状关系。方法：收集44例VED和44例对照组行静息态功能磁共振扫描。要求所有受试者完成一系列调查问卷，评估疾病的严重程度和精神状态。计算固有自发大脑活动并比较两组间差异，进一步分析VED患者固有自发大脑活动与临床症状关系。结果：与对照组相比，VED患者显示固有自发大脑活动异常模式:左侧舌回和左侧扣带回后部fALFF显著增加，更广泛脑区fALFF显著降低（主要位于额叶、左侧中央前回和一些默认网络区域）。而且VED患者的一些脑区与临床量表显著相关。结论：VED患者显示固有自发大脑活动异常，这些改变与临床症状显著相关。

Abstract：Objectives: To investigate the alteration of the intrinsic spontaneous brain activity of the vasculogenic erectile dysfunction(VED) patients by the fractional amplitude of low-frequency fluctuations(fALFF) index of resting state functional MRI, and to explore if the clinical symptoms of the VED patients is associated with their intrinsic brain activity.Methods: Forty-four VED and 44 healthy controls male subjects were collected by resting state functional magnetic resonance imaging. All participants were asked to complete a series of questionnaires to assess the severity of disease and the status of psychiatry. Intrinsic spontaneous brain activity was calculated and compared between VED and healthy control groups. The relationship between intrinsic spontaneous brain activity and clinical symptoms in VED patients was also investigated.Results: Compared with the healthy control male subjects, VED patients showed abnormal patterns of intrinsic spontaneous brain activity, which was characterized by significant increase fALFF in left lingual gyrus and left posterior cingulate and significant decreased fALFF in more widely brain regions mainly located in frontal lobe, left precentral and some default model network(DMN) areas. Moreover, certain regions of VED patients showed a significant correlation with SDS, NIH-CPIS and PEDT scores.Conclusions: Abnormal intrinsic spontaneous brain activity patterns were observed in VED patients, and these alterations showed a significant correlation with clinical symptoms of VED patients.