Study on the effect of acupuncture at Sìshéncōng (四神聪 EX-HN 1) and Bǎihuì (百会 GV 20) on the serum amino acids neurotransmitters of insomnia patients 针刺四神聪、百会对失眠患者血清氨基酸类神经递质的影响

作者：孙梦晓 来源：本站原创 点击：2370次 更新：1523844687

　　<p>PAN Yu (潘&nbsp; 瑜)¹,&nbsp; &nbsp;LUO Ji (罗&nbsp; 辑)²,&nbsp; &nbsp;ZHANG Hong-lei (张洪雷)¹ </p><p><br/></p><p style="text-align: justify;">1. Acupuncture-Moxibustion Department, Chongqing Traditional Chinese Medicine Hospital, Chongqing 400021,China; 2. Traditional Chinese Medicine Department, Fuling Center Hospital of Chongqing City（1. 重庆市中医院针灸科，重庆 400021，中国；2. 重庆市涪陵中心医院中医科）</p><p><br/></p><p>ARTICLE INFO</p><p><br/></p><p>First author: PAN Yu (1986- ), female, attending doctor.</p><p>Research field: treatment for insomnia, stroke and facial paralysis. E-mail: 642021358@qq.com</p><p>&nbsp; Corresponding author: ZHANG Hong-lei (1971- ), male, associate chief physician.</p><p>Research field: integrated traditional Chinese and western medicine treatment for respiratory system, endocrine system and nervous system diseases.</p><p>E-mail: 38983631@qq.com</p><p>Accepted on January 16, 2017</p><p><br/></p><p><br/></p><p>ABSTRACT</p><p><br/></p><p style="text-align: justify;">Objective&nbsp; To explore the efficacy of acupuncture at Sìshéncōng (四神聪 EX-HN 1) and Bǎihuì (百会 GV 20) as well as the possible mechanism. Methods&nbsp; Eighty cases of insomnia patients treated in our hospital were selected, and randomly divided into a control group and a treatment group according to the random number table method. Conventional treatment was carried out in the control group by giving diazepam tablets, and acupuncture at EX-HN 1 and GV 20 was conducted in the treatment group. The sleep time and quality, PSQI score, and the level changes of blood glutamic acid (GLU), γ-aminobutyric acid (GABA), norepinephrine (NE) and dopamine (DA) were compared in the patients in each group before and after treatment. Results&nbsp; Compared with the results before treatment, the time for falling asleep of the patients in the two groups shortened (both P&lt;0.05), the levels of GLU and GABA increased (all P&lt;0.05), the sleep time was longer (both P&lt;0.05), and the levels of NE and DA, as well as the PSQI score reduced (all P&lt;0.05). Compared with the control group, the levels of NE and DA, as well as the PSQI score of patients in the treatment group reduced after treatment (P&lt;0.05), the time for falling asleep shortened (P&lt;0.05), the levels of GLU and GABA increased (P&lt;0.05), and the sleep time was longer (P&lt;0.05). Conclusion Acupuncture at EX-HN 1 and GV 20 can prolong the sleep time, improve the sleep quality, and the clinical efficacy is superior to that of western medicine treatment. The mechanism may be related to the synthesis and release of amino acids neurotransmitters.</p><p><br/></p><p>KEY WORDS: Insomnia; acupuncture; Sìshéncōng (四神聪 EX-HN 1); Bǎihuì (百会 GV 20)</p><p><br/></p><p><br/></p><p>ABSTRACT IN CHINESE</p><p><br/></p><p style="text-align: justify;">[摘 要] 目的：探讨针刺四神聪、百会治疗失眠疗效及其可能的机制。方法：失眠患者80例按照随机数字表法随机分为对照组及治疗组，对照组以地西泮片常规治疗，治疗组予针刺四神聪、百会治疗。比较两组患者治疗前后睡眠时间、质量、PSQI功能评分及谷氨酸（LGU）、γ-氨基丁酸（GABA）、去甲肾上腺素（NE）、多巴胺（DA）水平及变化情况。结果：与治疗前比较，两组患者入睡时间均缩短（P＜0.05），睡眠时间均延长（P＜0.05），GLU、GABA均提高（均P＜0.05），NE、DA水平、PSQI功能评分均降低（P＜0.05）。与对照组相比较，治疗组患者治疗后NE、DA水平、PSQI功能评分均较低（P＜0.05），GLU、GABA均提高（P＜0.05），入睡时间缩短（P＜0.05），睡眠时间延长（P＜0.05）。结论：针刺四神聪、百会可延长睡眠时间、提高睡眠质量，临床疗效优于西药治疗。其机制可能是诱导氨基酸类神经递质合成与释放。</p><p style="text-align: justify;">[关键词] 失眠 针刺 四神聪 百会</p><p><br/></p>