Research progress on central mechanism of acupuncture treatment for chronic fatigue syndrome
Bin-bin LI（李彬彬）a，Chu-wen FENG（冯楚文）a,b，Yuan-yuan QU（屈媛媛）a，Zhong-ren SUN（孙忠人）c，Tao CHEN（陈涛）a，Yu-lin WANG（王玉琳）d，Qing-yong WANG（王庆勇）a，Jing LU（鲁菁）a，Yu-ying SHAO（邵玉莹）a，Tian-song YANG（杨添淞）b,c
a Graduate School of Heilongjiang University of Chinese Medicine, Harbin 150040, China (黑龙江中医药大学研究生学院，哈尔滨 150040，中国)
b Department of Acupuncture-Moxibustion, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040, China (黑龙江中医药大学附属第一医院针灸科，哈尔滨 150040，中国)
c Heilongjiang key Laboratory of Clinical (Encephalopathy) Neurobiology of Acupuncture and Moxibustion, Harbin 150040, China (黑龙江针灸临床（脑病）神经生物学省重点实验室，哈尔滨 150040，中国)
d Department of Acupuncture-Moxibustion, Second Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150001, China (黑龙江中医药大学附属第二医院针灸科，哈尔滨 150001，中国)
Chronic fatigue syndrome is a neurological disorder characterized by extreme fatigue that lasts for a long time and doesn't alleviate with rest. The number of the cases has been increasing during the era of COVID-19 pandemic. Acupuncture may have some effect on chronic fatigue syndrome, but its mechanism remains unclear. This article was to summarize the specific manifestations of abnormal central mechanism in patients with chronic fatigue syndrome through laboratory tests and neuroimaging. It was found from the laboratory evaluation that there were changes in the structure of the frontal cortex, thalamus and other brain tissues; factors, including IFN-α and IL-10 in cerebrospinal fluid were found abnormal; results of oxidative and nitrosative stress and changes in neurobiochemical substances, e.g. hypothalamus hormone levels and neurotransmitter concentrations, were observed. With magnetic resonance imaging and positron emission tomography, it was shown that the partial brain of persons with chronic fatigue syndrome had morphological changes with diminished grey matter and white; changes in cerebral blood flow velocity caused by decreased perfusion and functional activity with abnormal connectivity in brain were detected. In addition, there was significant decrease in glucose metabolism accompanied with neuroinflammatory response; metabolic disorders of serotonergic, cholinergic, glutamatergic and γ-aminobutyric acid energy neurotransmitters were also discovered. The regulatory effect of acupuncture on the above central neurological abnormalities in chronic fatigue syndrome model animals was elaborated, and the direction for further research was analyzed in order to provide ideas for further research on the central mechanism of acupuncture treatment for chronic fatigue syndrome.