Jun-wei GU(顾俊薇)a, Xu-ming YANG (杨旭明)b, Qi LI (李琪)a, Mu-en GU (顾沐恩)a, Meng-die WU (吴梦蝶)a, Shu-fei CAO (曹淑菲)c, Jing LI (李璟)a*

aYueyang Integrative Chinese and Western Medicine Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China (上海中医药大学附属岳阳中西医结合医院 上海 200437， 中国)

bShanghai University of Traditional Chinese Medicine, Shanghai 201023, China (上海中医药大学 上海 201023， 中国)

cClinic of Laochenghuangmiao Tonghaichuntang clinic, Shanghai 200010, China (老城隍庙童涵春堂门诊部， 上海 200010， 中国)

☆Supported by National Natural Science Foundation of China: 81674071; Shanghai TCM technological innovation program: ZYKC201601002

*Corresponding author

Email address: lj0806@hotmail.com （Jing LI）

ABSTRACT

Objective: To observe the differences in the effects and mechanisms on chronic gastritis treated by  ginger-isolated moxibustion at Zúsānlĭ  (足三里ST 36) and Nèiguān (内关PC 6).

Methods: A total of 60 eligible patients of chronic gastritis were randomized into two groups, a ST 36 group (ginger-isolated moxibustion at ST 36, 30 cases) and a PC 6 group (ginger-isolated moxibustion at PC 6, 30 cases). Before and after 6 treatments, the total variability of heart rate (TV) and the scores in Scale for gastrointestinal diseases of traditional Chinese medicine were determined and recorded. Using correlation analysis, the hidden correlation condition that affects the therapeutic outcomes was excavated from the data. With least square method, the gradient curve (K value) of TV in treatment was estimated and the correlation between the effect mechanism and autonomic nerve regulation was excavated.

Results: ① In ST 36 group, the duration of sickness, severity of disease and the activity of autonomic nerve before treatment presented the underlying correlation with the therapeutic effects. In contrast, the hidden correlation in PC 6 group was not clear. ② In ST 36 group, the higher  K value of TV in treatment was, the more significant the therapeutic effects were, but in PC group, K value was reversely related to the therapeutic effects.

Conclusion: The therapeutic effects of ginger-isolated moxibustion at single acupoint are correlated with the duration and severity of sickness. The therapeutic effects in ST 36 group were improved by the modulation of autonomic nerve activity and the effects in PC 6 group were negatively correlated with autonomic nerve activity. It is deduced that the effect mechanisms are different on single acupoint for chronic gastritis between the two points.

Keywords: Isolated ginger moxibustion, Chronic gastritis, Data mining, Association algorithm

[摘 要]

目的：观察隔姜灸对足三里和内关治疗慢性胃炎的作用及机制的差异。

方法：将60例符合条件的慢性胃炎患者随机分为两组，即足三里组（隔姜灸足三里, 30例）和内关组（隔姜灸内关, 30例）。分别于治疗前后测定心率总变异性（TV）及胃肠道疾病量表评分。通过相关分析，从数据中挖掘出影响治疗效果的隐性相关条件。用最小二乘法估计治疗中TV的梯度曲线（K值），挖掘其作用机制与自主神经调节的相关性。

结果：①足三里组患者的病程、病情严重程度、治疗前自主神经活动度与治疗效果有一定的相关性。与之相反，内关组间的隐性相关不明显。②足三里组治疗中TV的K值越高，疗效越显著，内关组则K值与疗效呈负相关。

结论：隔姜灸单穴位的疗效与病程及病情严重程度有关。足三里组通过调节自主神经活动改善疗效，内关组疗效与自主神经活动呈负相关。推测慢性胃炎单穴治疗的作用机理不同。

[关键词] 隔姜灸，慢性胃炎，数据挖掘，关联算法