Clinical observation of cancer-related fatigue treated with ginger-isolated moxibustion in the patients with gastric cancer

隔姜灸治疗胃癌患者癌因性疲乏的临床观察

Na SONG(宋娜)a, Yue-yunlu ZHAO (赵玥韵璐)b, Hong-jian XU (徐宏建)a, Jing WANG (王静)a, Zong-lang LAI (赖宗浪)a, Xin YU (余欣)c, Yue WU (吴玥)c*

a Department of Oncology, Chongqing Municipal Chinese Medicine Hospital, Chongqing 400021, China (重庆市中医院肿瘤科, 重庆400021, 中国)

b Chongqing Jiangbei District Daqing Community Health Service Center, Chongqing 400021, China (重庆市江北区大庆村社区卫生服务中心, 重庆400021, 中国)

c Department of Gastroenterology, Chongqing Municipal Chinese Medicine Hospital, Chongqing 400021, China (重庆市中医院消化内科, 重庆400021, 中国) 

*Corresponding author.

E-mail address:Aptxrose@sina.cn (Y. Wu)

Supported by Performance Incentive and Guidance Special Project of Scientific Research Institution, Chongqing Science and Technology Committee: cstc2018jxjl130008; Chongqing Science and Health Joint-project of TCM Technology Innovation and Application Development Project of Chongqing Health Committee and Chongqing Science and Technology Bureau: 2020ZY3571; Performance Incentive and Guidance Special Project of Scientific Research Organization, Chongqing Science and Technology Committee: cstc2020jxjl0020

ABSTRACT

Objective: To observe the clinical therapeutic effect of ginger-isolated moxibustion on cancer-related fatigue (CRF) in the patients with gastric cancer.

Methods: The patients in the conventional treatment group accepted conventional chemotherapy. In the ginger-isolated moxibustion group, on the base of the conventional chemotherapy, ginger-isolated moxibustion was added at Shénquè (神阙CV8), Shàngwăn (上脘CV13), Zhōngwăn (中脘CV12), Qìhăi (气海CV6) and Guānyuán (关元CV4). Chemotherapy for 3 weeks was as 1 cycle and 2 cycles of chemotherapy were observed.

Results: After treatment, plasma cortisol(Cor) was increased and adreno-cortico-tropic-hormone(ACTH) decreased in the ginger-isolated moxibustion group, indicating the statistical differences as compared with the levels before treatment (P < 0.05), and the differences in plasma Cor and ACTH were significant statistically between the two groups (P < 0.05). After treatment, the score of each item of the revised fatigue scale was reduced in the ginger-isolated moxibustion group, indicating the statistical differences as compared with the score before treatment (P < 0.05). The score of the revised fatigue scale was different statistically between the two groups (P < 0.05). After treatment, the score of each of the items, i.e. fatigue, nausea & vomiting, pain, dyspnea, insomnia, anorexia, constipation, diarrhea and financial difficulty, was reduced in the ginger-isolated moxibustion group, indicating the statistical differences as compared with the score before treatment successfully (P < 0.05). The differences were significant statistically in fatigue, nausea & vomiting, pain, dyspnea, insomnia, anorexia, constipation, diarrhea and economic difficulty between the two groups (P < 0.05).

Conclusion: Ginger-isolated moxibustion achieves a satisfactory effect on CRF in the patients with gastric cancer and deserves to be promoted in clinical practice.

Keywords: 

Ginger-isolated moxibustion

Gastric cancer

Cancer-related fatigue

Randomized controlled trial(RCT)

[摘 要]

目的：观察隔姜灸治疗胃癌患者癌性疲乏的临床疗效。

方法：常规治疗组采用常规化疗。隔姜灸组在常规化疗的基础上加用隔姜灸，分别在神阙、上脘、中脘、气海和关元。化疗3周为1周期，观察化疗2周期。

结果：隔姜灸组治疗后血浆皮质醇（Cor）升高，促肾上腺皮质激素（ACTH）降低，与治疗前比较差异有统计学意义（P<0.05），两组比较差异有统计学意义（P<0.05）。隔姜灸组治疗后修订后的疲劳量表各项评分均降低，与治疗前比较差异有统计学意义（P<0.05）。两组修订后的疲劳量表评分差异有统计学意义（P<0.05）。隔姜灸组治疗后疲劳、恶心呕吐、疼痛、呼吸困难、失眠、厌食、便秘、腹泻、经济困难等各项评分均较治疗前下降，与治疗成功前比较差异有统计学意义（P<0.05）。两组在疲劳、恶心呕吐、疼痛、呼吸困难、失眠、厌食、便秘、腹泻、经济困难等方面差异有统计学意义（P<0.05）。

结论：隔姜灸治疗胃癌CRF疗效满意，值得临床推广。

[关键词]隔姜灸、胃癌、癌症相关疲劳、随机对照试验