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针刺蝶腭神经节对改善健康人鼻腔通气功能及自主神经功能的机制调节的随机对照研究

作者:孙梦晓 来源:本站原创 点击:129次 更新:2018-12-18

陈陆泉1,2  王奎吉1 王 阳3  王成硕1  张 罗1

1. 首都医科大学附属北京同仁医院,北京 100730  2. 北京市中西医结合耳鼻喉研究所,北京10005  3.北京市耳鼻咽喉科研究所,北京 100005

摘要: 研究目的 探讨针刺蝶腭神经节对正常志愿者鼻腔通气功能和自主神经功能的影响。研究方法 将 39例受试者随机分为针刺组与对照组,每组各 25 例。针刺组进行标准的针刺蝶腭神经节刺激,对照组进行假针刺刺激,分别在针刺前、针刺后 30 min、2 h 及24 h 进行评估。评估指标为自报鼻腔通气的变化、鼻腔通气功能检查 ( 鼻阻力与鼻声反射 ) 、鼻腔呼出气一氧化氮。针刺疼痛程度评分、鼻腔分泌物中神经递质水平变化(包括P物质、血管活性肠肽、神经肽Y)。研究结果 与对照组比较,针刺组有更高比例的受试者汇报鼻腔通气改善,鼻阻力下降,鼻腔容积增加,且针刺后 24 h 鼻腔呼出气一氧化氮水平较对照组明显下降。与对照组相比,针刺组鼻腔分泌物中神经肽Y在针刺后30  min及2 h明显升高,P物质仅在30 min时升高;而血管活性肠肽浓度在各时间点无明显变化。 研究结论 针刺蝶腭神经节能够有效改善鼻腔通气,能够刺激兴奋鼻腔交感神经。

关键词: 针刺; 蝶腭神经节; 鼻腔通气; 交感神经

Sphenopalatine  Ganglion Acupuncture Improves Nasal Ventilation and Modulates Autonomic Nervous Activity in Healthy Volunteers: A Randomized Controlled Study

Luquan Chen1,2, Kuiji Wang1 , Yang Wang3, Chengshuo Wang1 ,Luo Zhang1


1Beijing TongRen Hospital, Capital Medical University, Beijing 100730  2 Beijing Institute of traditional Chinese and Western medicine for Otolaryngology,Beijing 100005   3. Beijing Institute of Otolaryngology ,Beijing 100005

Abstract:  Objective The study aimed to assess the effects of Sphenopalatine ganglion (SPG) acupuncture on nasal ventilation function and autonomic nervous system in health volunteers. 

Study Design/Materials and Methods: 39 healthy subjects were randomly assigned to either active SPG acupuncture group (AA group) or sham-SPG acupuncture group (SA group). All subjects were assessed for self-reported nasal ventilation, nasal patency (nasal airway resistance (NAR) and nasal cavity volume (NCV), exhaled nasal nitric oxide (nNO), and neuropeptides (substance P(SP), vasoactive intestinal peptide (VIP) and neuropeptideY (NPY)) in nasal secretions at baseline, 30 minutes, 2 hours, and 24 hours after acupuncture. Results: Significantly more subjects in AA group reported improvements in nasal ventilation at all time points after acupuncture, compared to SA group. NAR and NCV were also significantly lower in AA group than SA group. The level of nNO in AA group was significantly decreased after 24 hours compared to SA group. The level of NPY was significantly increased in AA group at 30 minutes and 2 hours compared to baseline and SA group. The levels of SP and VIP were not significantly different in the two groups.Conclusions: We concluded that SPG acupuncture could help to improve nasal ventilation by increasing sympathetic nerve excitability in healthy volunteers.

Key words: Acupuncture; Sphenopalatine ganglion; Nasal ventilation; sympathetic nerve

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